News

Say goodbye to jet lag

Say goodbye to jet lag

Photo: clipart.com

LONDON (Reuters) – Scientists have found a genetic mechanism in mice that hampers their body clock’s ability to adjust to changes in patterns of light and dark, and say their results could someday lead to the development of drugs to combat jet lag.

Researchers from Britain’s Oxford University and from the Swiss drug firm Roche used mice to analyze patterns of genes in an area of the brain called the suprachiasmatic nuclei (SCN) – which in mammals pulls every cell in the body into the same biological rhythm.

They found that one molecule, called SIK1, is key to how the mice responded to changes in light cycles.

When the scientists blocked the activity of SIK1, the mice recovered faster from disturbances in their daily light and dark cycle that had been designed to induce a form of mouse jet lag.

If the corresponding mechanism can be found and similarly blocked in humans, jet lag may become a thing of the past, the researchers said in their study, published online in the journal Cell on Thursday.

“We’re still several years away from a cure for jet lag, but understanding the mechanisms that generate and regulate our circadian clock gives us targets to develop drugs to help bring our bodies in tune with the solar cycle,” said Russell Foster, director of Oxford’s sleep and circadian neuroscience institute.

He said such drugs could also have broader potential value, including for people with mental illnesses where sleep disturbances are common.

Recent Headlines

in Entertainment

Oh no! ‘Bennifer’ are divorcing

bennifer

Actors Jennifer Garner and Ben Affleck say they've decided to divorce after 10 years of marriage.

in Music

Journey drummer Castronovo charged with rape

deencastrono

The rocker also faces charges including assault and menacing and is being held without bail in an Oregon jail.

in Entertainment

Men bring the moves, but ladies take charge in ‘Magic Mike XXL’

14-overlay11

The film, which hits theaters July 1, follows 2012's surprise hit with Channing Tatum rejoining the Kings of Tampa, his rogue band of male entertainers.

in Entertainment

EL James takes ‘Fifty Shades’ of heat during Twitter Q&A

eljames

#AskELJames backfired in terrific style because of course it did.

in Entertainment

20 years after ‘Showgirls,’ Elizabeth Berkley comes ‘full circle’

berkley

The former "Saved by the Bell" actress starred as an exotic dancer in the film, which was initially slammed by critics and flopped at the box office.